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Real members of MyMigraineTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Aimovig V. Ajovy V. Emgality

A MyMigraineTeam Member asked a question 💭
Buffalo, NY

Have any of you taken more than one of the preventative CGRPs (Aimovig, Ajovy, Emgality)? Did one work better than the others?

July 3, 2021
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A MyMigraineTeam Member

I've tried all three, emgality I think seemed to make the headaches worse and make them last longer, 14 days and worst pain and vomiting. Aimovig didn't do anything at all. Ajovy has changed things up I have gone from 5-6 migraines/week to 3-4. Going for 3-4 days in a row with no migraine is absolutely wonderful. The first time that happened I hardly believe it, ajovy is my drug of choice!!

July 3, 2021
A MyMigraineTeam Member

I was on Aimovig for about 6 months or so. Other than SEVERE constipation, it didn’t do a thing for me. Ajovy was tried next, but I had an allergic reaction to it. Last but not least, I’ve been on Emgality for about a year or so. I would say it has lessened the intensity of the migraines, unless they are weather related. It’s a small victory, but a victory nonetheless. Ubrelvy is an abortive that has not helped me very well, and neither has Nurtec. I’m a very complex case because I not only have chronic intractable migraines, I also have chronic cluster headaches. Different ways of treating each one. I try to remain hopeful that something will help get rid of these monsters, or at least make them less frequent!

July 3, 2021
A MyMigraineTeam Member

I have been on Imgality for like 6 months. The shot hurts for a few minutes. But it has reduced the number of major Migraines I have monthly. I was having about 4 debilitating migraines a week. I am down to maybe 2 MAJOR Migraines a month.

July 3, 2021
A MyMigraineTeam Member

Same here. 😥

August 24, 2021
A MyMigraineTeam Member

Yeah @A MyMigraineTeam Member, the side effects of the ones they seem to give us for migraine are often quite alarming. Like take Topomax for example, I think most of us were probably out on that at some point as it’s now considered the first line treatment. But it’s literally nicknamed Dopamax for how loopy it can make people! Luckily I’ve been on a low enough dosage that it didn’t do that to me, and they stopped raising the dosage because it stopped working after a few months of usage. But, none of us want to turn into zombies! Depakote was the first treatment they wanted to put me on when I was first diagnosed so i said no thank you and wasn’t treated with medication for six years—until my migraines became chronic and had no choice but to seek treatment. I probably should have just found a different neurologist, in hindsight. But I chose to just live with the pain at the time because I wanted to keep my faculties, my hair, and my figure and didn’t know there were any other options. The other option they suggested was Haldol. And I was like, wow why are you suggesting these insane medications to me?! Absolutely not! Pain it is.

July 18, 2021

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