Glucagon-like peptide 1 (GLP-1) receptor agonists, commonly referred to as GLP-1 drugs, are widely recognized for their use in managing type 2 diabetes and supporting weight loss. However, as more people use these medications, some have reported side effects, including headaches or migraine attacks.

If you’re living with migraine, it’s natural to wonder if these medications could affect your condition. This article will explain how GLP-1 drugs work, discuss their potential link to migraine, and provide tips on what to do if you experience headaches while taking these treatments.

What Are GLP-1 Drugs?

GLP-1 receptor agonists are a class of drugs primarily prescribed to manage type 2 diabetes. They work by mimicking the actions of glucagon-like peptide 1, a hormone that helps regulate glucose (blood sugar) levels after meals. GLP-1 drugs stimulate the release of insulin when blood sugar is elevated, inhibit the release of glucagon (a hormone that raises glucose), and slow stomach emptying, helping people feel fuller for longer.

In recent years, these medications have also been approved for weight management in people with obesity or higher body weights, even if they don’t have diabetes.

Commonly prescribed GLP-1 drugs include injectable forms such as:

• Dulaglutide (Trulicity)
• Exenatide (Bydureon BCise, Byetta)
• Liraglutide (Victoza)
• Semaglutide (Ozempic, Wegovy)

There’s also an oral form of semaglutide (Rybelsus).

Although these medications are effective for controlling blood sugar and promoting weight loss, they can have adverse effects. One potential side effect that users have reported is headaches.

GLP-1 Drugs and Migraine: Is There a Connection?

Headaches are a possible side effect of GLP-1 receptor agonists, and some people may experience migraine attacks while taking GLP-1 drugs. However, migraine isn’t typically listed as a direct side effect of these medications. The most common side effects of GLP-1 drugs are gastrointestinal, such as nausea, vomiting, and diarrhea. Researchers are exploring potential links between GLP-1 drugs and headaches.

Several studies have shown that a small percentage of people using GLP-1 receptor agonists experience headaches, but even these results are unclear. For example, one clinical trial reported that 15.2 percent of participants experienced headaches after higher-dose semaglutide, compared to 12.2 percent of participants receiving a placebo (an inactive treatment). That made it difficult for researchers to determine if the headaches were caused by the drug itself or by other factors. Despite the uncertainty, any potential increased risk of headache is noteworthy to people who live with migraine.

Response to GLP-1 Drugs Varies

Individual responses to GLP-1 can differ greatly. Some people may experience only minor headaches, but for others who are prone to migraine, these headaches may progress to migraine attacks. Tracking your symptoms when starting a GLP-1 drug can help you understand how your body responds. It’s also important to remember that other factors, such as your lifestyle choices and stress, also can contribute to headaches or migraine.

Just how GLP-1 drugs cause headaches isn’t fully understood. Researchers believe that these medications may influence blood sugar and hydration levels, both of which are common migraine triggers. For example, hypoglycemia (low blood sugar) can lead to headaches. Additionally, the slowed digestion caused by GLP-1 drugs may affect hydration or nutrient absorption, potentially triggering migraine headaches.

New Evidence That GLP-1 Drugs May Help Certain Migraine Headaches

While GLP-1 receptor agonists may trigger headaches in some people, recent research has uncovered a potential benefit for people with specific headache disorders. A systematic review explored the role of GLP-1 drugs in managing headaches, particularly migraine and idiopathic intracranial hypertension (IIH).

Idiopathic intracranial hypertension is a condition characterized by increased pressure inside the skull without an obvious cause, often resulting in severe headaches and vision problems. Since weight loss is a primary treatment for IIH, and GLP-1 drugs promote weight loss, these medications are being studied as a possible treatment option for this condition.

Like IIH, migraine headaches involve complex neurological processes, such as inflammation, changes in blood flow, and increased nerve sensitivity. Although IIH specifically increases pressure in the skull, the mechanisms through which GLP-1 drugs help reduce pressure in IIH could offer valuable insights into how these medications might affect migraine. For example, animal studies have shown that GLP-1 receptor agonists can reduce pain signaling, including the activity of calcitonin gene-related peptide, and lower neuroinflammation — both of which are key players in the development of migraine.

This growing body of evidence hints at the potential for GLP-1 drugs to play a role in migraine management. However, more human clinical studies are needed to fully explore this possibility.

Management of Migraine While on GLP-1 Drugs

If you experience headaches or migraine headaches while taking a GLP-1 receptor agonist like Ozempic, you can take some steps to manage your symptoms.

Consult Your Health Care Provider

If you notice that your migraine worsens or headaches become more frequent after starting a GLP-1 medication, talk to your doctor. They may adjust your dosage or recommend an alternative medication. Some people find relief by switching to another GLP-1 drug that may cause fewer headaches.

Monitor Blood Sugar Levels

Fluctuations in blood sugar can trigger migraine headaches. If you’re using GLP-1 drugs to manage diabetes, work with your health care provider to carefully monitor your glucose levels. Keeping your blood sugar stable can help prevent headache-triggering hypoglycemia.

Stay Hydrated

Dehydration is a common migraine trigger. Be sure to drink plenty of water, especially if you’re experiencing nausea or vomiting as a side effect of a GLP-1 medication. Staying well hydrated may help reduce the likelihood of migraine headaches.

Consider Alternative Treatments

If your migraine headaches persist despite these strategies, your health care provider may recommend switching to another type of diabetes medication or weight loss drug. Other classes of medications may have fewer side effects for people prone to headaches.

Mixed Results But Promising Future

GLP-1 receptor agonists are effective tools for managing type 2 diabetes and supporting weight loss. However, they may come with side effects, including headaches or migraine attacks. While headaches aren’t a common side effect, individuals with migraine should consult a health care provider if symptoms get worse.

At the same time, emerging research suggests that GLP-1 drugs may have a role in treating certain types of headaches, such as those related to intracranial hypertension. If you experience migraine headaches while taking GLP-1 drugs, speak with your doctor to figure out the best course of action. Balancing the benefits and potential side effects of these medications will help you find the best treatment for your needs.

Talk With Others Who Understand

MyMigraineTeam is the social network for people with migraine and their loved ones. On MyMigraineTeam, more than 83,000 members come together to ask questions, give advice, and share their stories with others who understand life with migraine.

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