HYPOTHESIZED PATHOPHYSIOLOGY OF MIGRAINE
Migraine is a neurovascular disorder associated with dysfunction of the cerebral nerves and blood vessels.2,3 Although early theories posited the cerebral blood vessels as the site of origination of migraine attacks, current hypotheses place the primary dysfunction in the brain—probably in brainstem centers important in regulating vascular tone and pain sensation. In current hypotheses, migraine-specific triggers cause primary brain dysfunction, which causes dilation of cranial blood vessels that are innervated by sensory fibers of the trigeminal nerve to dilate.2,3 The dilated blood vessels mechanically activate perivascular trigeminal sensory nerve fibers. Activation of trigeminal sensory nerve fibers causes a pain response to be conveyed to the brainstem (and from there to higher brain centers) and evokes release of vasoactive peptides such as substance P and CGRP from trigeminal fibers.
Peptides exacerbate vasodilation and cause neurogenic inflammation characterized by vasodilation, leakage of blood vessels, and degranulation of mast cells.
The vasodilation and neurogenic inflammation further increase activation of the sensory trigeminal fibers, perpetuate the release of vasoactive peptides including CGRP, and modulate transmission of pain impulses to the brain. As migraine progresses, the brainstem and spinal cord centers that are the first to receive the pain impulses from the trigeminal nerve are hypothesized to become sensitized with a resultant worsening of headache pain and increased sensitivity to environmental and other stimuli.

Unfortunately sometimes there are no answers been 25 years. My doctor who is a top neurologist in California has suffered from migraines her whole life I think that why she head of the migraine department at a major institution. She still get migraines frequently just no answers sorry.

Stress and certain foods or smells. Mine are definitely stress and certain scents, I can only wear one particular perfume.
I’ve had severe migraines for over 60 years and Botox injections and Qulipta have changed my life. I thank God I have a caring neurologist.

Stress, family, work, anything around u that will cause mirgianes and food too

They have no idea what causes migraines